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GSH biosynthesis is generally performed by two consecutive ATP-consuming reactions catalyzed by -glutamylcysteine synthetase (-GCS, GSHI) and glutathione synthetase (GS, GSHII) from three precursors in microorganisms: l-glutamate, l-cysteine, and glycine [1]

However, a recent large meta-analysis showed no association between these three variants and low bone mineral density or fracture prevalence (102)

Patients on metformin and another antihyperglycemic agent (N=229) and patients not on any antihyperglycemic agents (off therapy for at least 8 weeks, N=41) were randomized after a run-in period of approximately 10 weeks on metformin HCl (at a dose of at least 1500 mg per day) in monotherapy